Table 2.
Risk score model validated in TAHOD cohort
| Outcome | TAHOD - Full risk score | TAHOD-LITE - Short risk score | ||
|---|---|---|---|---|
| Number of participants included in the validation | 6,092 | 9,717 | ||
| Developed CKD, N (%) | 391 | 6.4% | 520 | 5.4% |
| Incidence of CKD/1,000 PYFU (95%CI) | 8.1 | (7.3, 8.9) | 10.5 | (9.6, 11.4) |
| Risk score model | ||||
| Baseline score, median (IQR) | −2 | (−6, 1) | −1 | (−6, 1) |
| Baseline score for those who developed CKD, median (IQR) | 5 | (0, 10) | 5 | (1, 10) |
| Events by score group: low/medium/high | 90/99/202 | 106/147/267 | ||
| Incidence of CKD/1,000 PYFU (95%CI) | ||||
| Low (risk score < 0) | 2.8 | (2.2, 3.4) | 3.1 | (2.5, 3.7) |
| Medium (risk score 0-4) | 10.2 | (8.4, 12.4) | 14.3 | (12.2, 16.8) |
| High (risk score ≥5) | 33.2 | (28.9, 38.1) | 54.6 | (48.4, 61.6) |
| Incidence rate ratio | ||||
| Low (risk score < 0) | 0.27 | (0.20, 0.36) | 0.21 | (0.17, 0.27) |
| Medium (risk score 0-4) | 1 | 1 | ||
| High (risk score ≥5) | 3.27 | (2.57, 4.15) | 3.81 | (3.12, 4.66) |
| Number at risk for CKD at 5 year: low/medium/high | 3027/916/563 | 3103/924/407 | ||
| Kaplan-Meier percent progressed at 5 yr (95%CI) | ||||
| Low (risk score < 0) | 1.31 | (0.99, 1.73) | 1.51 | (1.21, 1.89) |
| Medium (risk score 0-4) | 5.53 | (4.33, 7.04) | 7.01 | (5.86, 8.37) |
| High (risk score ≥5) | 19.24 | (16.65, 22.17) | 24.99 | (22.26, 27.98) |
| Number at risk for CKD at 10 year: low/medium/high | 1316/409/271 | 569/173/88 | ||
| Kaplan-Meier percent progressed at 10 yr (95%CI) | ||||
| Low (risk score < 0) | 2.7 | (2.15, 3.4) | 3.49 | (2.67, 4.56) |
| Medium (risk score 0-4) | 8.92 | (7.18, 11.05) | 11.68 | (9.59, 14.19) |
| High (risk score ≥5) | 26.10 | (22.99, 29.54) | 32.4 | (28.6, 27.98) |
| aIRR (95%CI) per unit increase in score | 1.21 | (1.19, 1.23) | 1.24 | (1.22, 1.25) |
Abbreviations: CKD, chronic kidney disease; PYFU, person-years of follow-up; CI, confidence interval; aIRR, adjusted risk ratio.