Table 1.
Baseline Patient Demographics
| Variables | 18 Months Data | 3+ Years Data | |
|---|---|---|---|
| Rapid Decliners | Non-Rapid Decliners | ||
| Number of Patients | 72 | 10 | 17 |
| Males: Females | 28 M: 44 F | 3 M: 7 F | 6 M: 11 F |
| Age (years) | 52.0 (20–81) | 54.5 (30–70) | 56.6 (20–81) |
| BMI (kg/m2) | 25.7 (23.1–28.8) | 25.1 (22.9–27.3) | 24.5 (23.3–26.8) |
| Smoking (Never (N): Ex) | 46 N: 26 Ex | 9 N: 1 Ex | 14 N: 3 Ex |
| Pack Years (Ex) | 8.0 (2.3–12.3) | 18.0 (18.0–18.0) | 14.0 (7.2–26.0) |
| FEV1% Predicted | 105.5 (93.3–118.3) | 108.5 (93.5–123.8) | 105.0 (97.0–122.0) |
| ∆ FEV1 (%Pred/Yr) | −0.91 (−3.17 to +1.00) | −2.11 (−2.81 to −1.33) | 0.42 (−0.17 to +0.73)* |
| FVC % Predicted | 117.5 (107.9–132.0) | 135.9 (124.3–140.5) | 119.0 (104.0–128.0)** |
| FEV1/FVC (%) | 75.8 (67.4–81.5) | 74.6 (65.6–76.5) | 80.0 (70.3–83.0) |
Notes: Demographics for all 72 patients with spirometry data measured prospectively every 6 months over 18 months. 27 had previous annual spirometry measurements for at least 3 years. Based on these data, this subgroup was further differentiated into rapid and non-rapid decliners as defined previously.10 All continuous data are presented as median (interquartile range), except age which is presented as median (range). *p = 0.027; **p <0.001 for rapid vs non-rapid decliners, for both.