TABLE 2.

In silico analysis of the CDK5RAP2 variants.

Variant	Protein effect	ClinVar	DANN	EIGEN	MutPred	MutationTaster	SIFT	PolyPhen-2
c.1156C > T	p.Thr274LysfsTer27	NR	0.9987	Pathogenic	Pathogenic	Disease causing	Damaging	Probably damaging
c.280C > T	p.Glu275ArgfsTer16	NR	0.9993	Pathogenic	Pathogenic	Disease causing	Damaging	Probably damaging