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. 2021 Mar 19;12:626359. doi: 10.3389/fendo.2021.626359

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Copyright © 2021 Silamiķele, Silamiķelis, Ustinova, Kalniņa, Elbere, Petrovska, Kalniņa and Kloviņš

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Body weight and microbiome diversity analysis. (A) Mean body weight of each of the experimental groups in each of the weeks. Dashed line indicates the beginning of metformin treatment. (B) Changes in alpha diversity in each of the groups expressed as an effective number of species. (C) Beta diversity in each of the groups before the beginning of metformin treatment. (D) Beta diversity in each of the groups after 10 weeks long metformin treatment. Samples representing each experimental unit in each of the experimental groups are shown as dots.