Table 1.

Biochemical parameters before and after metformin treatment.

Group		Before treatment			After treatment
		Glucose, mmol/L	Insulin, pmol/L	HOMA-IR	Glucose, mmol/L	Insulin, pmol/L	HOMA-IR
HFD_M_Met-	Mean	12.21	730.14	7.37	11.11	2079.39	17.91
	SD	1.68	449.58	4.79	4.04	385.61	9.95
HFD_F_Met-	Mean	12.17	309.25	2.89	14.06	661.08	6.71
	SD	1.66	147.92	1.19	1.63	250.64	1.82
HFD_M_Met+	Mean	15.01	1537.10	18.31	11.77	1666.22	14.33
	SD	0.80	526.92	5.92	2.81	525.32	4.59
HFD_F_Met+	Mean	11.46	457.83	4.06	12.00	613.48	5.35
	SD	1.50	256.10	1.91	1.18	358.59	2.76
CD_M_Met-	Mean	11.69	127.82	1.21	12.03	194.80	1.68
	SD	2.89	48.07	0.51	1.01	162.22	1.27
CD_F_Met-	Mean	8.81	96.50	0.67	10.04	127.33	1.01
	SD	1.73	10.09	0.07	2.25	57.42	0.59
CD_M_Met+	Mean	10.15	221.05	1.71	9.23	133.04	0.93
	SD	1.69	234.81	1.75	0.51	131.09	0.96
CD_F_Met+	Mean	8.29	124.45	0.78	9.43	122.71	0.86
	SD	2.24	46.60	0.21	0.25	14.93	0.09
	Group	**	*	*	*	***	***
	Treatment	NS	NS	NS	NS	NS	NS
	Diet	**	**	**	*	***	***
	Sex	*	NS	*	NS	*	NS
	Block	NS	NS	NS	NS	NS	NS

N = 3 in each of the studied groups. Significance codes: 0 (***), 0.001 (**), 0.01 (*), >0.05 (NS).