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. Author manuscript; available in PMC: 2021 Apr 2.
Published in final edited form as: Nature. 2019 Nov 27;576(7785):163–167. doi: 10.1038/s41586-019-1781-3

Fig. 5 |. Schematic of the RUR-induced inhibition mechanism.

Fig. 5 |

Conformational changes are shown between EDTA–CALHM2hemi (a) and RUR–CALHM2 (b). The observed movement of helix S1 and the proposed movement of the NTH during channel inhibition are indicated. The region that cannot be modelled is indicated by dashed lines.