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. Author manuscript; available in PMC: 2021 Apr 2.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2017 May 24;14(8):479–490. doi: 10.1038/nrgastro.2017.56

Figure 2 |. Clinical approach to refractory EoE.

Figure 2 |

A suggested treatment algorithm for patients with eosinophilic oesophagitis (EoE) after a PPI trial who do not respond to a either topical steroid or dietary elimination treatment. When a patient might have non-response, the first step is to evaluate the potential causes of non-response and correct them. If non-response is confirmed, the next step will depend on the initial treatment strategy. If the original treatment was with topical steroids, then this modality could be optimized or the patient could be switched to dietary elimination. If the original treatment was dietary elimination, this could be maximized or the patient could be treated with topical steroids. If there is continued non-response, there are a wide range of options the choice of which will depend on the patient and disease characteristics. Often these patients are suitable candidates for participation in clinical trials of emerging treatment agents.