Skip to main content
. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Chem Soc Rev. 2021 Mar 1;50(4):2224–2243. doi: 10.1039/d0cs01261k

Fig. 3.

Fig. 3

Examples of RNA dynamic regulation and associated functional consequences. (A) N6-methyladenosine (m6A) modification disfavors WCF base pairing (top), promoting single-stranded hairpin formation in MALAT1 and consequent enhanced binding of the heterogeneous nuclear ribonucleoprotein C (hnRNP C, bottom). Adapted from ref. 24 with permission from Springer Nature, Copyright 2015. (B) The ground state (GS) of HIV-1 TAR RNA is more strongly bound by the Cyclin T1-Tat protein complex than the less energetically stable excited state. Adapted from ref. 26 with permission from Springer Nature, Copyright 2012.