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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Chem Soc Rev. 2021 Mar 1;50(4):2224–2243. doi: 10.1039/d0cs01261k

Fig. 4.

Fig. 4

Examples of common noncovalent interactions in RNA–small molecule recognition. Adapted from ref. 29 with permission from The Royal Society of Chemistry, Copyright 2020. (A) Binding of two acridine-based ligands to the Telomeric Repeat-Containing RNA (TERRA) via stacking interactions (PDB ID: 3MIJ). Ball denotes a K+ ion. (B) Hydrogen bonding interactions (dashed lines) between paromomycin and HIV-1 Dimerization Initiation Site (DIS) (PDB ID: 3C44).