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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Chem Soc Rev. 2021 Mar 1;50(4):2224–2243. doi: 10.1039/d0cs01261k

Fig. 7.

Fig. 7

Structural dynamics of HIV-1 TAR are modulated with small molecules. (A) TAR oscillates between a ground state (GS) and excited state (ES) characterized by base flipping and angular rearrangement of the helix. Several ligands, including argininamide and DMA-169, were shown to alter excited state accessibility, whereas other ligands such as neomycin were not. Adapted from ref. 43 with permission from Elsevier, Copyright 2020. (B) The structures of argininamide, DMA-169, and neomycin.