Figure 5.

20p11 is associated with normal facial variation

(A) LocusZoom plots for the association of normal facial variation and rs6036034. Points are color-coded based on linkage disequilibrium (R²) in Europeans. The asterisks represent genotyped SNPs, and the circles represent imputed SNPs.

(B) The normal displacement (displacement in the direction locally normal to the facial surface) in each quasi-landmark of the facial segment reaching the lowest p value in MetaUS and MetaUK going from the minor to the major allele SNP variant. Blue, inward depression; red, outward protrusion.

(C) Global-to-local facial segmentation plot that shows the 63 facial segments represented in teal obtained using hierarchical spectral clustering.

(D) The −log10(p value) of the meta-analysis p values per facial segment in MetaUS and MetaUK. Black-encircled facial segments have reached a genome-wide p value (p = 5.00 × 10⁻⁸).