Table 1.
Baseline Characteristics
| Myectomy | Alcohol Ablation | P Value* | |
|---|---|---|---|
| Patients, n (%) | 378 (79.2) | 99 (20.8) | |
| Age, y | 52.7±14.7 | 66.3±11.9 | <0.001 |
| Women, n (%) | 158 (41.8) | 63 (63.6) | <0.001 |
| BMI, kg/m2 | 31.1±6.7 | 31.9±10.2 | 0.385 |
| Resting heart rate | 64±10 | 62±10 | |
| NYHA class (study entry), n (%) | |||
| I | 1 (0.3) | 0 (0) | |
| II | 25 (6.6) | 5 (5.1) | |
| III | 348 (92.1) | 93 (93.9) | |
| IV | 4 (1.1) | 1 (1) | 0.715 |
| Maximum LV thickness, mm | 20.3±4.8 | 19.6±2.9 | 0.155 |
| LV wall thickness ≥30 mm | 15 (4.0) | 0 (0) | <0.001 |
| LV wall thickness ≤16 mm | 66 (17.5) | 9 (9.1) | <0.05 |
| LVOT gradient at rest, mm Hg | 58.0±41.8 | 65.7±40.7 | 0.105 |
| LVOT gradient at rest ≥30 mm Hg, n (%) | 280 (74.1) | 76 (76.8) | 0.583 |
| Moderate or severe mitral regurgitation, n (%) | 127 (34) | 37 (37) | 0.481 |
| LVEF, % | 65±5 | 65±5 | 0.931 |
| History of atrial fibrillation, n (%) | 116 (30.7) | 16 (16.2) | <0.005 |
| Syncope, n (%) | 49 (13.0) | 4 (4.0) | <0.05 |
| NSVT on ambulatory Holter | 44 (11.6) | 16 (16.2) | 0.281 |
| Family history of SCD | 35 (9.3) | 2 (2.0) | <0.05 |
| Medications, n (%) | |||
| β-Blocker | 290 (76.7) | 81 (81.8) | 0.381 |
| Calcium channel blocker | 143 (37.8) | 36 (36.4) | 0.765 |
| Disopyramide | 33 (8.7) | 11 (11.1) | 0.607 |
| Amiodarone | 8 (2.1) | 8 (8.1) | <0.005 |
| ACE inhibitors/ARB | 47 (12.4) | 27 (27.3) | <0.001 |
| Diuretic | 66 (17.5) | 28 (28.3) | <0.05 |
| Coumadin | 35 (9.3) | 9 (9.1) | 0.959 |
| History, n (%) | |||
| COPD | 33 (8.7) | 8 (8.1) | 0.838 |
| CVA | 19 (5.0) | 7 (7.1) | 0.412 |
| Diabetes mellitus | 42 (11.1) | 16 (16.2) | 0.171 |
| CKD | 5 (1.3) | 11 (11.1) | <0.001 |
| Liver disease | 8 (2.1) | 7 (7.1) | <0.05 |
| Cancer | 27 (7.1) | 2 (2.0) | 0.058 |
| Cardiac surgery | 3 (0.8) | 2 (2.0) | 0.287 |
| Comorbidity indices | |||
| Modified Charlson Score | 2.6±1.5 | 3.7±1.7 | <0.001 |
| EuroSCORE II | 1.0±0.6 | 1.2±0.9 | <0.005 |
| Goodman HHS Criteria Score | 2.9±1.6 | 3.4±1.9 | <0.01 |
| STS mortality score, % | 1.0±0.6 | 2.0±1.5 | <0.001 |
Values are mean±SD or n (%). ACE indicates angiotensin-converting enzyme; ARB, angiotensin II receptor blocker; BMI, body mass index; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; HHS, Health and Human Service; LV, left ventricle; LVEF, left ventricular ejection fraction; LVOT, left ventricular outflow tract; NSVT, nonsustained ventricular tachycardia; NYHA, New York Heart Association; SCD, sudden cardiac death; and STS, Society of Thoracic Surgeons.
*
P value is for comparison of myectomy vs alcohol ablation.