Figure 3.

The fMRI data-processing workflow for comparing task activation predictions based on task-state versus resting-state FC. Publicly available Human Connectome Project fMRI data (young adult dataset; N = 352) was split into separate discovery and replication datasets (N = 176 each). Circularity is carefully avoided in the predictions by (1) FIR regression to remove cross-block mean task responses before task-state FC estimation, and (2) removal of each to-be-predicted brain region from the set of predictors in the activity flow-mapping step. The goal of the primary analyses is to compare task activation predictions based on resting-state FC to predictions based on task-state FC.