Figure 4.

Increased tonic glutamatergic current in αSyn transgenic mice. A, Representative whole-cell recording with a patch electrode of tonic glutamatergic currents in CA1 pyramidal neurons from acute hippocampal slices of WT and αSyn transgenic mice at a holding potential of (Vh) = −70 mV. The tonic basal currents were larger in the αSyn transgenic mice versus WT (42 vs 14 pA). B, Quantification of basal tonic current blocked by CPP + CNQX (n = 4 slices each). Data are mean ± SEM. *p < 0.05 (Student's t test).