Figure 5.

Oligomerized αSyn-evoked eNMDAR activity triggers dendritic spine loss. A, Representative images of dendritic spines labeled by Golgi staining in mouse hippocampal slices. B, Quantification of dendritic spines showing that blockade of eNMDAR activity by NitroSynapsin abrogated dendritic spine loss mediated by oligomerized αSyn. For each treatment, there were two independent experiments; and in each independent experiment, there were two slices. For each slice, at least three neurons were imaged; and spines were counted on six dendrites for each of these neurons. Data are mean ± SEM. **p < 0.01; ****p < 0.0001; one-way ANOVA with Bonferroni post hoc test.