Figure 7.

Oligomeric αSyn induces NMDAR-mediated currents in hiPSC-derived cerebrocortical neurons. A, Whole-cell recording of hiPSC-derived neurons showing that αSyn oligomers evoked inward current in hiPSC neurons, which was largely inhibited by the NMDAR antagonist APV. Bottom, Same recording on a faster timescale. B, Quantification of normalized area under the curve (AUC) showing NMDAR-mediated current in 10 s epochs of recordings induced by αSyn oligomers, determined by addition of APV (n = 4 neurons in 4 independent experiments). Data are mean ± SEM. ***p < 0.001 (Student's t test).