Figure 8.
Schematic diagram showing dual oligomeric αSyn action on neurons and astrocytes. Right, αSyn directly activates eNMDAR-operated channels. Left, αSyn induces astrocytic glutamate release, which leads to further activation of eNMDARs. This aberrant eNMDAR activity in turn contributes to synaptic damage and loss. Created with www.BioRender.com.