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Schematic model for the regulation of axon regeneration by BRC-1–BRD-1. Under normal conditions, BRC-1–BRD-1 is localized in the nucleus. In response to axon injury, PKA phosphorylation of BRC-1 Ser-266 induces the translocalization of BRC-1–BRD-1 to the cytoplasm. The BRC-1–BRD-1 complex poly-ubiquitylates DGK-3, resulting in its degradation. BRC-1–BRD-1 enhances the EGL-30 signaling pathway to promote axon regeneration.
