Fig. 8.

Density plot suggesting the complementarity (overlapping area) and dissimilarity between leads from natural products identified from in silico-based studies and reported USFDA approved drugs under anti-infective category during the year 2015–20 using various key molecular descriptor employed. The descriptors include A. Molecular weight (MW); B. Topological polar surface area (TPSA); C. number of rotational bonds (nROTB); D. hydrogen bond donors (nHBDon); E. acceptors (nHBAcc); and F. implication of partition coefficient (AlogP).