Table 5.
The table illustrates median, mean and standard deviation (SD) values for molecular descriptors employed against reported USFDA approved drugs under anti-infective category during year 2015–20.
| FDA anti-infective | MW (g/mol) |
TPSA (Å2) |
nROTB |
nHBDon |
nHBAcc |
AlogP |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median | Mean | SD | Median | Mean | SD | Median | Mean | SD | Median | Mean | SD | Median | Mean | SD | Median | Mean | SD | |
| Year 2015 | 631.67 | 610.44 | 142.53 | 173.29 | 176.61 | 49.88 | 13 | 11.5 | 6.45 | 3 | 3 | 0.81 | 11 | 11 | 2.58 | −1.60 | −1.59 | 1.97 |
| Year 2017 | 311.62 | 345.13 | 168.06 | 81.82 | 82.33 | 4.126 | 5 | 5.25 | 2.21 | 1 | 1.25 | 0.5 | 5 | 5.25 | 2.21 | 0.13 | 0.13 | 1.51 |
| Year 2018 | 564.66 | 556.74 | 99.60 | 149.90 | 153.09 | 69.10 | 6 | 6.62 | 3.77 | 4 | 4.25 | 3.65 | 10.5 | 10 | 3.77 | −0.31 | −1.12 | 3.00 |
| Year 2019 | 433.18 | 493.86 | 185.30 | 110.79 | 146.86 | 111.29 | 6 | 7.5 | 5.19 | 2 | 2.5 | 2.64 | 5.5 | 7 | 4.83 | 0.71 | 0.27 | 3.35 |
| Year 2020 | 583.158 | 523.18 | 120.76 | 187.05 | 166.23 | 58.16 | 10 | 9.66 | 4.50 | 2 | 2.33 | 1.52 | 14 | 12.3 | 3.78 | −3.21 | −2.02 | 2.13 |