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. 2021 Apr 3;296:100630. doi: 10.1016/j.jbc.2021.100630

Figure 5.

Figure 5

The effect of anti-IL-1R7 antibody on LPS-induced cytokine production in human whole blood culture. Human whole blood cultures were pretreated with or without 5 μg/ml anti-IL-1R7 or 10 μg/ml IL-1Ra or 1 μg/ml IL-18BP for at least 30 min before they were stimulated with 10 ng/ml LPS for 3 days. A, effect of anti-IL-1R7 on LPS-induced IFNγ in the whole blood culture. B, effect of anti-IL-1R7 on LPS-induced TNFα in the whole blood culture. C, effect of anti-IL-1R7 on LPS-induced IL-6 in the whole blood culture. Mean ± SD Percent change of LPS-induced cytokine production in human whole blood culture with various concentrations of anti-IL-1R7 or IL-18BP or IL-1Ra (n ≧ 5). ∗∗∗p < 0.001, ∗∗p < 0.01, and ∗p < 0.05, compared with LPS alone.