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. 2020 Jul 28;34(2):249–260. doi: 10.1007/s10334-020-00868-y

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© The Author(s) 2020

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Fig. 6 — Sagittal proton-density weighted (PDw) images and corresponding glycosaminoglycan chemical exchange saturation transfer (gagCEST) maps of a 29-year-old healthy male (a and b) and an age-matched male patient with an established osteochondral lesion of the talus (OLT; c, d, e). a Unremarkable tibiotalar joint with no sign of cartilage damage, osteoarthritis or OLT. c Osteochondral lesion of the anterior talus (black arrowhead), osteophyte of the anterior tibia (white arrowhead), and intra-tissue signal hyperintensity of the anterior tibiotalar joint cartilage indicative of focal cartilage damage (long arrow). e More medial to (c), presence of a large cystic OLT in the weight-bearing aspect of the talus (long arrow) representing a stage 5 OLT according to the Hepple classification and an osteophyte of the anterior tibia (arrowhead). Overall, the tibiotalar joint cartilage is focally thinned, inhomogeneous, and irregular. b and d The tibiotalar joint cartilage of the healthy volunteer has higher gagCEST values than the patient (color-coded gagCEST maps overlaid onto T1w morphological image)