Fig. 1.

a Reaction of phenylglyoxal with the arginine moiety in peptides yields imidazolidine diol. b Overview of CTX (yellow) and mToxin (red) binding to the complementary acetylcholine-binding protein (AChBP). Chains A and B of AChBP are colored in green and blue respectively (PDB ID: 1YI5). c A closeup of A and B subunits’ ACh binding site with modified CTX and natural CTX. d The binding scores of the top docking results for CTX and mToxin, accepted by PatchDOCK. e The binding areas of the CTX and mToxin with the receptor, accepted by PatchDOCK