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. 2021 Jan 8;58(5):2322–2341. doi: 10.1007/s12035-020-02270-0

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© The Author(s) 2021

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Fig. 2 — Representative whole-cell recordings from PC-12 cells stimulated with various agents. a ACh (30 μM) induces a typical brief response. Application of mToxin does not induce any response. b Potent selective α7AchR agonist AR-R 17779 (1 μM) mimics ACh (30 μM) and induces a similar response in the presence of the positive allosteric modulator of α7AchR, PNU120596. Note the overwhelming response of α7AChR, but not of α1AChR. c Natural toxin (α-bungarotoxin) and mToxin do not induce any current in PC-12 cells. d mToxin reduces (by about 75%) the amplitude of AR-R 17779-induced currents. Note, that mToxin is a partial antagonist of α7AChR