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. 2021 Jan 8;58(5):2322–2341. doi: 10.1007/s12035-020-02270-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Improvement of basal synaptic transmission and rescue of hippocampal LTP with mToxin treatment. a Hippocampal LTP in the CA1 area. Soluble aged Aβ inhibited LTP (red tracing) induced by high-frequency stimulation (HFS, arrow), and was restored by mToxin (yellow tracing, n = 9) to its control level (blue tracing, n = 9). mToxin alone had no significant effect on LTP (gray tracing, n=9). b Effects of Aβ and mToxin on the maintenance phase of LTP, 115–120 min after HFS. c PPF at different ISI with various treatments, d PPF ratios recorded at 30 ms ISI. e PPF ratios recorded at 100 ms ISI. *p<0.05, **p<0.01, ***p<0.001, #p<0.0001