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. 2021 Apr 2;11:7457. doi: 10.1038/s41598-021-86764-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Lipoic acid biosynthesis as cause of small colony phenotype in Enterobacter hormaechei isolated from a bloodstream infection in a patient with end-stage renal disease. Genomic sequencing of the paired NCV and SCV isolates revealed multiple genomic lesions including single nucleotide substitutions in entD, hemN, and pqqB along with large-scale rearrangements leading to disruption of the lipA gene. (a) Genetic rescue with lipA restored normal growth from the Enterobacter hormaechei SCV. (b) Chemical rescue with lipoic acid restored normal growth in Enterobacter hormaechei SCV. (c) Cross-feeding from Enterobacter hormaechei NCV restores growth of SCV, consistent with a diffusible factor required for growth. All plates in this figure were incubated under aerobic conditions.