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. 2021 Apr 2;11:7471. doi: 10.1038/s41598-021-86946-0

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Scatter plot expression of Shh signaling pathway genes and their regulatory miRNAs in tumoral and adjacent non-tumoral tissues. Gene expression variations were considered in 50 gastric adenocarcinoma patients. Each plot represents a person’s gene expression change in tumor tissue in comparison with adjacent normal tissue. Horizontal lines represent cut-off values corresponding to log two-fold changes in expression. The upper and lower parts of the horizontal lines indicate upregulation, and downregulation in the tumoral tissues in comparison with non-tumoral tissues, respectively.