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. 2021 Apr 2;11:7470. doi: 10.1038/s41598-021-87091-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of tankyrase inhibitor XAV939 on the viability and colony formation capacity of HCC lines. (A) HCC cell lines were treated with XAV939 at 1 μM or 5 μM for three days followed by a MTT-assay (n = 4). No statistical significant growth reduction was observed (unpaired t-test). (B) Fold changes observed in a colony formation assay following XAV939/IWR-1 treatment. Only significant changes are shown (mean ± SD, n = 6, *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; unpaired t-test).