Table 3.

The study of complement activation in mice models during coronavirus infection

Genotype	Collective evidence of complement activation	References
WT	Complement is activated after SARS-CoV MA15 (the mouse-adapted SARS-CoV) infection as demonstrated by elevated C3 activation products (C3 fragments C3a, C3b, iC3b, C3dg, and C3c)	Gralinski et al. [32]
C3−/−	C3−/− mice showed a partial reduction of respiratory dysfunction, pathology, immune cell infiltration, and cytokine responses in the lung, compared with WT mice	Gralinski et al. [32]
B−/−	Factor B−/− mice had less weight loss than WT mice	Gralinski et al. [32]
C4−/−	C4−/− mice had less weight loss than WT mice	Gralinski et al. [32]