FIGURE 3.

Inhibition of lysophosphatidic acid receptor 5 (LPAR5) suppresses thyroid cancer cell proliferation and migration. A, Relative cell viability was detected by MTT assay upon treatment with TC LPA5 4 at different concentrations for 72 h. B, The effect of TC LPA5 4 on the migration abilities of thyroid cancer cells was detected by transwell assay (magnification × 4). **Compared with control group, P < .01. C, Relative mRNA expression of thyroid‐specific genes, such as NIS, TPO, and Tg in CGTH‐W3, TPC‐1, B‐CAPAP, and BHT101 cells. D, Inhibition of tumor growth by TC LPA5 4 against CGTH‐W3 xenografts