Table 3.

Annotation System Technology (RAST) server annotation functional subsystems classification of 6 hypervirulent Klebsiella pneumoniae and the Klebsiella pneumoniae reference strain NTUH-K2044

Subsystem	Number of genes
	K038	K090	K095	K323	K396	K406	NTUH-K2044
Cofactors, vitamins, prosthetic groups, pigments	368	400	365	370	371	370	364
Cell wall and capsule	219	220	218	213	226	222	217
Capsular and extracellular polysacchrides	43	44	41	37	50	46	41
Gram-negative cell wall components (90)	90	90	91	90	90	90	90
Cell wall and capsule—no subcategory	86	86	86	86	86	86	86
Virulence, disease and defence	148	140	133	128	138	145	128
Adhesion	7	7	7	7	7	7	7
Bacteriocins, ribosomally synthesized antibacterial peptides	12	12	12	12	12	12	12
Resistance to antibiotics and toxic compounds	115	113	100	95	105	112	95
Invasion and intracellular resistance	14	8	14	14	14	14	14
Potassium metabolism	34	35	33	33	33	34	33
Miscellaneous	66	65	66	67	68	69	68
Phages, prophages, transposable elements, plasmids	14	53	32	22	18	29	4
Membrane transport	218	223	231	208	267	223	213
Iron acquisition and metabolism	105	113	72	75	65	109	76
Siderophores	52	60	24	23	17	54	24
Iron acquisition and metabolism—no subcategory	53	53	48	52	48	55	52
RNA metabolism	251	253	251	249	249	255	250
Nucleosides and nucleotides	138	138	138	141	142	142	140
Protein metabolism	320	288	312	304	304	315	306
Cell division and cell cycle	43	40	42	41	42	43	38
Motility and chemotaxis	9	9	9	10	11	11	11
Regulation and cell signaling	180	184	176	171	167	179	164
Secondary metabolism	5	5	5	5	17	5	5
DNA metabolism	130	118	121	132	138	132	131
Fatty acids, lipids, and isoprenoids	140	144	139	139	134	145	138
Nitrogen metabolism	49	47	47	46	47	63	62
Dormancy and sporulation	5	5	5	5	5	5	5
Respiration	180	183	182	191	187	184	180
Stress response	180	181	180	182	183	183	180
Metabolism of aromatic compounds	79	79	79	82	78	85	85
Amino acids and derivatives	572	550	548	544	545	546	536
Sulfur metabolism	79	80	79	80	79	82	81
Phosphorus metabolism	69	67	67	68	69	69	67
Carbohydrates	863	896	849	846	875	878	872
Total	4464	4516	4379	4352	4458	4523	4354