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Mechanism of PLpro inhibition-mediated inactivation of SARS-CoV-2. Ubiquitination and ISGylation are critical events in the innate immune responses against viruses. PLpro of SARS-CoV-2 helps the virus in evading host immunity by reversing these two critical steps. Thus, inhibitors against PLpro are hypothesized to counter this evasion mechanism of the virus. This might prevent the virus from replicating as well
