Table 1.

Toxicity and experimental prediction of FDA approved drugs

Drug name	Ames toxicity	Max tolerated (human)(log mg/kg/day)	HERG I inhibitor	HERG II inhibitor	Oral acute toxicity (LD50) mol/kg	Oral chronic toxicity (LOAEL) (log mg/kg_bw/day)	Hepatotoxicity	Skin sensitization	T. pyriformis (logµg/L)
Predicted toxicity of drug
Bromocriptine	No	− 0.915	No	Yes	3.739	2.693	No	No	0.285
Methysergide	Yes	− 0.515	No	Yes	2.642	1.013	Yes	No	0.316
Methylergometrine	Yes	− 0.723	No	Yes	2.81	1.078	No	No	0.299
Pergolide	Yes	− 0.266	No	Yes	2.919	1.846	Yes	No	1.006
Cabergoline	No	− 0.978	No	No	3.032	0.442	Yes	No	0.282
Experimental toxicity of drug
Bromocriptine	Nausea, vomiting, diarrhoea and severe hypotension
Methysergide	Tachycardia, hyperactivity, Euphoria, dilated pupils, and dizziness
Methylergometrine	Seizure, nausea, vomiting, hypertension
Pergolide	Nausea, Vomiting, decreased blood pressure, convulsions, and CNS stimulation
Cabergoline	Nasal congestion, syncope, or hallucinations