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Dose-dependent effect of hindbrain (4V) ventricle delivery of PrRP on 24 h body weight and ad libitum chow intake in n =14 animals. a PrRP reduced 24 h body weight change at doses of 0.1, 0.5, and 5 nmol relative to vehicle. b PrRP at the 0.5 and 5 nmol doses decreased cumulative chow intake at 8, 12, and 24 h. These effects were mediated by interactions between treatment and time for c average meal size and d cumulative meal number. * = p < .05; error bars represent SEM
