Table 3.
Parasite counts and efficacy.
| Parasite | Study/treatment groups | Number of positive cats/number of cats in group | Geometric mean parasite count (range) | Efficacy1 (%) | p-value2 |
|---|---|---|---|---|---|
| Adult Toxocara cati | Study 1, induced infection (Tennessee, USA) | ||||
| Placebo (control)3 | 10/10 | 29.5 (14–57) | 100 | <0.0001 | |
| Treated4 | 0/10 | 0 | |||
| Study 2, natural infection (Albania) | |||||
| Placebo (control) | 10/10 | 12.1 (2–32) | 98.8 | <0.0001 | |
| Treated | 1/10 | 0.1 (0–3) | |||
| Dipylidium caninum | Study 3, induced infection (South Africa) | ||||
| Placebo (control) | 7/8 | 28.9 (8–267) | 98.0 | 0.0018 | |
| Treated | 2/8 | 0.6 (3–9) | |||
| Study 4, natural infection (Albania) | |||||
| Placebo (control) | 9/10 | 23.1 (3–143) | 98.3 | 0.0001 | |
| Treated | 2/10 | 0.4 (1–12) | |||
| Study 5, natural infection (Mexico) | |||||
| Placebo (control) | 7/10 | 5.6 (1–370) | 93.2 | 0.0052 | |
| Treated | 1/10 | 0.4 (24) | |||
1
Percent efficacy = 100[(C − T)/C], where C was the geometric mean among placebo controls and T was the geometric mean among the treated animals.
2
Two-sided probability value from analysis of variance on log-counts of the treated group and the placebo control group.
3
Mineral oil at 0.12 mL per kg bodyweight spot-on, once.
4
NexGard® Combo at 0.12 mL per kg bodyweight spot-on, once.