Table 1.
Study contexts and designs.
| Studies | Lab #1 | Lab #2 | Field |
|---|---|---|---|
| Model | Induced infestation | Natural infestation | Natural infestation |
| Location/date | South Africa/Dec 2015 – March 2016 | Michigan, USA/Dec 2018 – Jan 2019 | Europe/Oct 2018 – Apr 2019 |
| O. cynotis strain origin | South Africa | USA | Hungary and Greece |
| Variable used for randomization | Bodyweight | Pre-treatment otoscopic live mite count | Order of presentation |
| Inlusion criteria | Both ear canals positive for mites | Both ear canals positive for mites | At least 1 motile ear mite in 1 ear canal |
| Number of treated/control cats | 8/8 | 10/10 | 32/33 sentinels*, 54/61 total* |
| Treatment dose | Minimum dose of 0.12 mL/kg | Minimum dose of 0.12 mL/kg | Commercial dose |
| Main variable of efficacy | Live O. cynotis counts collected in ear canals, Day 28 | Live O. cynotis counts collected in ear canals, Day 32 | Live O. cynotis counts collected in ear canals of sentinel animals, Day 30 (±3) |
| Secondary efficacy evaluations | Otoscopic assessment (scoring of debris/cerumen and live mites), Days −7, 7, 14, 21, 28 | None | Otoscopic assessment (scoring of pruritus and quality/quantity of cerumen), Day 0, Day 30 (±3) |
*
In the field trial, all cats in a household (total) were treated, one cat per household (sentinel) was evaluated for efficacy and safety, all other cats for safety.