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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2020 Dec 27;56(1):54–87. doi: 10.1080/10409238.2020.1856768

Figure 1. Domain structure of ADARs from various organisms.

Figure 1.

Overall domain structure of human (Homo sapiens, hs), fly (Drosophila melanogaster, dm), squid (Doryteuthis opalescens, sq), and nematode (Caenorhabditis elegans, ce) ADAR proteins. Structures highlighted include dsRNA binding domains (purple), C-terminal catalytic (deaminase) domains (blue), Z-DNA binding motifs (red, hsADAR1 only), and the arginine-rich R-domain (yellow, hsADAR3 only). Domain boundaries and protein length data was obtained from the UniProt database, accession numbers are as follows: hsADAR1 (P55265), hsADAR2 (P78563), hsADAR3 (Q9NS39), dmADAR (Q9NII1), sqADAR2a (C1JAR3), sqADAR2b (C1JAR4), ceADR-1 (Q9U3D6), ceADR-2 (Q22618).