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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2020 Dec 27;56(1):54–87. doi: 10.1080/10409238.2020.1856768

Figure 4. ADAR binding and editing of endogenous dsRNA prevents aberrant sensing of self dsRNA in nematodes, flies and mammals.

Figure 4.

ADARs can have both binding and editing effects that prevent the sensing of endogenous dsRNA structures by the indicated sensor proteins. Loss of ADAR leads to upregulation of antiviral, innate immune and interferon stimulated genes.