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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2020 Dec 27;56(1):54–87. doi: 10.1080/10409238.2020.1856768

Figure 5. Conservation of the deaminase domain sequences between human ADAR1, Drosophila ADAR and C. elegans ADR-2.

Figure 5.

Sequences of the deaminase domains for the indicated proteins were obtained from UniProt database using the accession numbers described for Figure 1. Sequences that are identical are shown in a red-filled box, while those meet consensus (> 70%, <100%) are boxed with consensus residues in red font. Variants in human ADAR1 p150 deaminase domain known to cause AGS (Rice et al., 2012) are indicated using symbols: A870T (#), I872T (*), R892H (!), K999N (^), G1007R(&), Y1112H (+) and D1113H ($). Please refer to Table 1 for detailed information about the consequences of these mutations on ADAR1 function.