Fig. 1. Transcriptonal heterogentiy of in vitro senescent cells.

Transcriptomic changes induced by various types of senescence are highly heterogeneous. The expression of only 7 genes is commonly changed in six fibroblasts and two endothelial cells during senescence induced by ionizing radiation, doxorubicin, oncogene activation, and telomere shortening. After senescence is induced, 727 genes are upregulated and 584 genes are downregulated in dataset A (Hernandez-Segura et al., 2017), while 50 genes are upregulated and 18 genes are downregulated in dataset B (Casella et al., 2019).