Table 1.
Association between perineural invasion (PNI) and other clinicopathological factors.
| PNI- (%) | PNI+ (%) | P value | |
|---|---|---|---|
| Nationality | <0.001 | ||
| Chinese | 428 (22.4) | 20 (1.9) | |
| Korean | 1486 (77.6) | 1035 (98.1) | |
| Gender | 0.055 | ||
| Male | 1311 (68.5) | 686 (65.0) | |
| Female | 603 (31.5) | 369 (35.0) | |
| Age | 0.028 | ||
| <60 | 1011 (52.8) | 602 (57.1) | |
| ≥60 | 903 (47.2) | 453 (42.9) | |
| Tumor location | <0.001 | ||
| Upper third | 303 (15.8) | 192 (18.2) | |
| Middle third | 412 (21.5) | 313 (29.7) | |
| Lower third | 1194 (62.4) | 545 (51.7) | |
| Whole stomach | 5 (0.3) | 5 (0.5) | |
| Tumor size | <0.001 | ||
| ≤2 cm | 531 (27.7) | 75 (7.1) | |
| 2.1-5 cm | 953 (49.8) | 521 (49.4) | |
| 5.1-8 cm | 339 (17.7) | 334 (31.7) | |
| >8 cm | 91 (4.8) | 125 (11.8) | |
| Differentiation of tumor | <0.001 | ||
| Well | 155 (8.1) | 33 (3.1) | |
| Moderate | 576 (30.1) | 236 (22.4) | |
| Poor | 1183 (61.8) | 786 (74.5) | |
| pT stage | <0.001 | ||
| T1 | 779 (40.7) | 18 (1.7) | |
| T2 | 405 (21.2) | 103 (9.8) | |
| T3 | 294 (15.4) | 286 (27.1) | |
| T4a | 415 (21.7) | 636 (60.3) | |
| T4b | 21 (1.1) | 12 (1.1) | |
| pN stage | <0.001 | ||
| N0 | 1084 (56.6) | 237 (22.5) | |
| N1 | 298 (15.6) | 172 (16.4) | |
| N2 | 257 (13.4) | 229 (21.7) | |
| N3a | 199 (10.4) | 262 (24.8) | |
| N3b | 76 (4.0) | 154 (14.6) | |
| Staging | <0.001 | ||
| Stage I | 953 (49.8) | 65 (6.1) | |
| Stage II | 457 (23.9) | 271 (25.7) | |
| Stage III | 504 (26.3) | 719 (68.2) | |
| Lymphatic invasion | <0.001 | ||
| Negative | 1470 (76.8) | 389 (36.9) | |
| Positive | 444 (23.2) | 666 (63.1) | |
| Vascular invasion | <0.001 | ||
| Negative | 1500 (78.4) | 371 (35.2) | |
| Positive | 414 (21.6) | 684 (64.8) | |
| Chemotherapy | <0.001 | ||
| No | 1277 (66.7) | 269 (25.5) | |
| Yes | 637 (33.3) | 786 (74.5) |