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. 2021 Mar 30;14:2279–2291. doi: 10.2147/OTT.S282947

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© 2021 Yang et al.

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BGN was a target gene of miR-320a and regulated by LINC00460. (A) Starbase3.0 revealed the predicted miR-320a binding site in the BGN 3ʹUTR, wildtype (WT) and mutated (MUT) 3ʹUTR of BGN was also shown. (B) The relationship between miR-320a and BGN expression of HNSCC patients in the TCGA database (C) Relative mRNA and protein levels of BGN in Cal-27 and FaDu cells transfected with miR-NC mimic, miR-320a mimic, miR-NC inhibitor, or miR-320a inhibitor. (D) miR-320a markedly reduced luciferase activity in LINC00460-wild not in LINC00460 mut in Cal-27 and FaDu cells. (E) BGN expression in HNSCC tissues and normal tissues in TCGA database. (F) The relationship between LINC00460 expression and overall survival time of HNSCC patients analyzed using the Kaplan-Meier method. (G) The relationship between LINC00460 and BGN expression of HNSCC patients in the TCGA database (H) Relative mRNA and protein levels of BGN in Cal-27 and FaDu cells transfected with sh-LINC00460 or sh-NC. (I) Relative mRNA and protein levels of BGN in Cal-27 and FaDu cells transfected with sh-NC+miR-NC inhibitor, sh-LINC00460-#2+miR-NC inhibitor, or sh-LINC00460-#2+miR-320a inhibitor. * P< 0.05, ***P < 0.001.