Figure 6.

Pharmacological inhibition of the dentate gyrus disrupts sensitivity to the low-dose alcohol cue. (A) Atlas images of confirmed bilateral cannulae placements (squares – males, circles – females), and representative photomicrograph showing injector tract. Behavior was measured by the primary dependent variable (mean±SEM): head entry discrimination score (B) in addition to corresponding duration in seconds (C). Discrimination score following baclofen/muscimol infusion in DG did not differ between water and alcohol pretreatment showing that silencing DG blunted sensitivity to low-dose alcohol. There were no effects on locomotor rate (D). *p<0.05 alcohol different from water.