Fig. 1.

An overview of the roles of BTK in myeloid cells. The processes highlighted in red boxes indicate roles of BTK signaling in myeloid cells that have been reported in human or mice in the setting of microbial infection and cancer. Details regarding each cellular process are outlined in the text. Abbreviations: BTK, Bruton’s tyrosine kinase; TLR, Toll-like receptors; MYD88, myeloid differentiation primary response 88; PLCγ2, phospholipase C gamma 2; NF-κB, nuclear factor-kappa B; NO, nitric oxide; IL-1β, interleukin 1 beta; IL-6, interleukin 6; TNF-α, tumor necrosis factor-alpha; IFN, interferon