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. 2021 Mar 22;12:594330. doi: 10.3389/fimmu.2021.594330

Figure 2.

Figure 2

Impairment of Becn+/- attenuates the bronchitis-like phenotypes in the CS+Eln model. Experimental outline was the same as Figure 1A , (A) Inflammatory cell counts in the BALF. (B) Representative images and semi-quantified scoring of H&E staining of mouse lung sections. Scale bar = 200 μm. (C–F) The Cxcl1, Cxcl2, Il6 and Ifng mRNA transcripts in lungs. (G–J) The protein concentrations of CXCL1, CXCL2, IL6 and IFNg in BALF. (K) Expression of Muc5ac mRNA transcripts in mouse lungs. (L) Representative images and the semi-quantified scorings of PAS staining in mouse lung sections. Scale bar = 100 μm. Labeling for all the columns throughout Figure 2 was shown in (A). Mac, macrophages; Neu, neutrophils; Lym, lymphocytes; Eos, eosinophils. Throughout, data are representative of 4-5 mice and were replicated in at least 3 independent experiments. Data are presented as mean ± s.e.m. *p < 0.05, **p < 0.01, ***p < 0.001 by one-way ANOVA.