Figure 1.

ADP accelerates wound healing in diabetic mice via P2Y₁₂. Representative images and graphs of diabetic (A) and non-diabetic (B) mice that were subjected to excisional full-thickness wounding, and then, topically treated with ADP 30 μM (30 μL - 15.4 µg/kg) or saline every day for 14 days. One group of mice was treated by gavage with Clop (5 mg/kg) 1 h before ADP and saline, both once a day for 14 days. Open wound area was measured at days 0, 3, 7, 10 and 14. The areas at day 0 were considered 100%, and the subsequent areas measured at different time-points were calculated as percentages (%) of the initial value. (C) Dose-effect data of ADP treatment followed at days 3, 7, 10, and 14 after wounding. Data are expressed as mean ± standard error of the mean. *P < 0.05 by two-way ANOVA followed by Bonferroni post-test, compared to saline-treated mice; n=7-10 per group. Panels A and B are representative of three or more experiments; panel (C) represents one experiment.