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. 2021 Mar 22;12:651740. doi: 10.3389/fimmu.2021.651740

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Copyright © 2021 Borges, Waclawiak, Georgii, Fraga-Junior, Barros, Lemos, Russo-Abrahão, Saraiva, Takiya, Coutinho-Silva, Penido, Mermelstein, Meyer-Fernandes, Canto, Neves, Melo, Canetti and Benjamim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of the pleiotropic effects of ADP on skin wound in diabetic mice. ADP topical instillation accelerates wound closure and improves tissue repair represented by type I collagen deposit and adequate reepithelization. The mechanisms seem to involve the increase of neutrophils, eosinophils, mast cells, M2 macrophages, myofibroblasts and Vγ4⁺ and Vγ5⁺ cells in the wound, besides its ability in modulating cytokine release. ADP plays pivotal role within inflammation, proliferation and remodeling phases during skin tissue repair in diabetes wounds.