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Schematic representation of the pathway that potentially connects neutrophil extracellular traps (NETs) with the formation of antibodies of IgG2 isotype in systemic lupus erythematosus. The various steps are detailed in the text. As for the last step that involves TLR9, the data supporting a direct link between NETs and IgG2 via TLR9 are presented in this special issue of Frontiers (The kidney in inflammatory and immune-mediated diseases) (see Bertelli et al.).
