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. 2021 Mar 22;8:632219. doi: 10.3389/fmolb.2021.632219

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Copyright © 2021 Glaß, Misiak, Bley, Müller, Hagemann, Busch, Rausch and Hüttelmaier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Properties of the putative IGF2BP1 targets. (A) Top 12 significantly (FDR <0.05) enriched biological processes and molecular functions found among the DPPs. (B) Dependency scores generated from data of 789 cell lines for the UNPs, DPPs and NDPs. (C, D) Log2 Hazard ratios (HR–high expression/low expression; patients separated by median expression values) of DPPs (C) and UNPs (D) in 31 solid tumor cohorts. The top box represents the median HRs of the respective genes in all cohorts. Statistical significance was assessed using the Mann-Whitney test. *: p < 0.05; ****: p < 0.0001; n. s.: p ≥ 0.05.