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. 2021 Mar 22;8:648259. doi: 10.3389/fmed.2021.648259

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Copyright © 2021 Gesper, Nonnast, Kumowski, Stoehr, Schuett, Marx and Kappel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic overview of experimental procedure of Langendorff model. (B) Serial injections of buffer, dobutamine, and IPA with intermittent washing steps in the Langendorff mouse model show dose-depended effects of IPA on left ventricle developed pressure (LVdp). Dobutamine (1 mg/ml, 1:256) was administered as positive control. (C) Percentage difference of LVdp in relation to baseline/wash between buffer, IPA, and wash. All data were shown as mean ± SD with N = 7/group. *p < 0.05, **p < 0.01, and ***p < 0.001 by 1-way ANOVA.